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Invariant natural killer T (iNKT) cells exist in a 'poised effector' state, which enables them to rapidly produce cytokines following activation. Regulation of hematopoiesis in vitro and in vivo by invariant NKT cells. An injury in which the tissue first suffers from hypoxia as a result of severely decreased, or completely arrested, blood flow. Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. 140, 119–129 (2011). J. Exp. Cardell, S. et al. Rev. Med. Sci. 174, 1787–1790 (2005). The crystal structure of human CD1d with and without α-galactosylceramide. Lopez-Sagaseta, J., Kung, J. E., Savage, P. B., Gumperz, J. Nature Med. PLoS ONE 6, e28648 (2011). Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells. J. Biol. Mathew, R. et al. Med. 168, 5514–5520 (2002). (CDR3). Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, One Jimmy Fund Way, Boston, 02115, Massachusetts, USA, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, 02115, Massachusetts, USA, You can also search for this author in Recognition of lyso-phospholipids by human natural killer T lymphocytes. Activation of invariant NKT cells by Toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Fujii, S., Shimizu, K., Kronenberg, M. & Steinman, R. M. Prolonged IFN-γ-producing NKT response induced with α-galactosylceramide-loaded DCs. 286, 37964–37975 (2011). Girardi, E. et al. 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Article  iNKT cells are frequently characterised by the recognition of the prototypical glycolipid, a–galactosylceramide (a-GalCer), a marine-sponge-derived agent, which also potently activates them and has strong anti-tumour activity. These cells … Immunity 22, 705–716 (2005). A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. CD1d-restricted invariant natural killer T (iNKT) cells are known as potent early regulatory cells of immune responses. 5, e1000434 (2009). Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. 204, 995–1001 (2007). 180, 5167–5171 (2008). One of the main features differentiating the adaptive immune system from its innate counterpart is the generation and expression of diverse antigen receptors. 171, 5140–5147 (2003). 207, 2383–2393 (2010). Targeting iNKT cells for the treatment of sickle cell disease. Chem. Godfrey, D. I. A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan. In the absence of β2-microglobulin, MHC class I molecules are unstable and are therefore found at very low levels on the cell surface. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. Curr. J. Immunol. J. Immunol. 191, 1895–1903 (2000). They have been shown to have important roles in many diverse immune responses. Neutrophilic granulocytes modulate invariant NKT cell function in mice and humans. PLoS Pathog. Invariant Natural Killer T (iNKT) cells are key players in the immunity to several pathogens; however, their involvement in the resistance to Paracoccidioides brasiliensis infection remains unknown.